5-ht-rezeptor depression Serotonin vermittelt seine physiologischen und pathophysiologischen Effekte über eine Aktivierung verschiedener, an die Zellmembran gebundener Rezeptoren, der 5-HT-Rezeptoren. Diese sind in hoher Dichte im Zentralnervensystem, im Magen-Darm-Trakt. 1 Der 5-HT1A-Rezeptor ist darüber hinaus als Zielstruktur zur Behandlung zentralnervöser Erkrankungen (beispielsweise Angstzustände und Depression) von. 2 HT-Rezeptor-Agonisten und –Antagonisten sind bereits im klinischen Alltag als. Antiemetika, Anxiolytika und zur Behandlung von Migräne vielfach erprobt. 3 Das serotonerge System und im Speziellen der Serotonin-Rezeptor 5-HT1A (5-HT1AR) sind maßgeblich an depressiven Erkrankungen beteiligt. Kürzlich wurde auch den. 4 The role of 5-HT receptors in depression. Depression is a polygenic and highly complex psychiatric disorder that remains a major burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are some of the most commonly prescribed drugs worldwide. 5 5-HT 4 R expression is also associated with the development of some behavioral features of depression, since the deletion of or pharmacological blockade of 5-HT 4 Rs results in increased depressive and anxiety-like behaviors in rodents [ 74, 90, 91 ]. 6 Major depressive disorder (MDD) is a ubiquitous illness that plagues more than million people worldwide across all races and socioeconomic groups [1, 2]. MDD often strikes early in life and remains a chronic or recurring lifelong illness, and is therefore responsible for more years lost to disability than any other illness [ 1 ]. 7 The brain serotonin (5-HT) system plays a crucial role in processing emotionally salient stimuli [1, 2].Brain 5-HT signaling appears to be altered in major depressive disorder (MDD), a disorder. 8 5-HT genes and depression. Studies of major depression in twins and families have shown moderate to high heritability, and much effort has been made to identify susceptibility genes linked to 5-HT. The 5-HTT gene (slc6a4) is one of the most intensively investigated genetic risk factors for depression. 9 The 5-HT neurons have the unusual capacity to regrow and reinnervate brain regions following insults such as brain injury, chronic stress, or altered development that result in disconnection of the 5-HT system and often cause depression, anxiety, and cognitive impairment. 5-ht-rezeptoren 10